The authors examined the association between cannabis use and cerebral cortex development in a longitudinal, community-based study of 2223 adolescents in Europe. Results suggest that cannabis use during middle to late adolescence is associated with altered cortical development, particularly in prefrontal regions which are rich in cannabinoid (CB)1 receptors. Moreover, follow-up analyses indicated a potential consequence of cannabis-related cortical thinning in the right dorsomedial prefrontal cortex from baseline to 5-year follow-up was associated with attentional impulsiveness at 5-year follow-up.
By Matthew D. Albaugh, PhD; Jonatan Ottino-Gonzalez, PhD; Amanda Sidwell, BS; et al.
Read the full study at JAMA Network.